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Lesson plan — Hypertension

The moments of the class

1. General introduction

2. The site

3. Simulations — first round (pre-class)

4. Class — Hypertension

5. Class — Cardiovascular risk

Blank prescription form, in two copies side by side, with the fields Name, Reg., Health Unit, Clinic, Outpatient or Emergency, a large space for the prescription, Date, and Signature and Stamp
Sample blank prescription form — the same paper as in the blank-sheet exercise.

What the regulation requires on the prescription. Under Law No. 5,991/1973, art. 35, as amended by Law No. 14,063/2020, a prescription is only filled if it is written in the vernacular, without abbreviations and legibly, in official nomenclature and units (item I); if it includes the patient's name and home address and, expressly, the way to use the medication (II); and if it includes the date, the health professional's signature, the address of the office or residence, and the professional council registration number (III). The same article says that the prescription is valid throughout the national territory, whichever entity issued it (§ 1), and that an electronic prescription is only valid with an advanced or qualified electronic signature — qualified is mandatory when the drug is under special control (§§ 2 and 3). In SUS, prescribing must use the generic name: DCB or, failing that, DCI (Law No. 9,787/1999). And a specially controlled medication does not go on this sheet: it goes on a Prescription Notification or a Special Control Prescription in two copies, in the model of SVS/MS Ordinance No. 344/1998.

menu_bookStep-by-step treatment — transcribed from PACK Brasil 2025, p. 145 ("Hypertension: treatment"). The full PDF is on the Hypertension page.

  1. Manage cardiovascular risk

    • Support for change (PACK p. 17) and manage modifiable CVR factors (p. 136) for 3 months.
    • After 3 months, if BP is not controlled, add step 2.
  2. Hidroclorotiazida 25mg/dia or enalapril 10–40mg/dia

    Hidroclorotiazida (HCTZ) 25mg/dia — primeira escolha.

    • Prescribe 25mg/day in the morning.
    • If DM, CKD, LV hypertrophy, or HF: start with enalapril in place of HCTZ and, if BP is not controlled in 4 weeks, add HCTZ.
    • Do not prescribe if pregnant, gout, eGFR < 30, or severe liver disease. Avoid if current or family history of skin cancer.

    Enalapril 10mg – 40mg/day — first choice if DM, CKD, LV hypertrophy, or HF.

    • Start with 10mg/day.
    • If BP is not controlled in 4 weeks, add HCTZ 25mg/day. If already on enalapril 10mg/day and HCTZ, increase to 20mg/day.
    • If already on enalapril 20mg/day, increase to 20mg every 12 hours. If still not controlled, add step 3.
    • Do not prescribe if pregnant or breastfeeding, prior angioedema, eGFR < 30. Do not start if potassium ≥ 5; stop if ≥ 5.5.

    Adverse effects. HCTZ: reduced glucose tolerance, gout, gastrointestinal changes, skin cancer risk. Enalapril: cough (replace with losartan 50–100mg/day, p. 46), dizziness. If swelling of the tongue, lips, or face, or shortness of breath: stop enalapril or losartan.

  3. Anlodipino 5–10mg/dia

    • If BP is not controlled with steps 1 and 2 (also consider amlodipine in Raynaud's disease — discuss): start with 5mg at night.
    • If BP is not controlled in 4 weeks, increase to 10mg/day. If still not controlled, add step 4.
    • Do not prescribe if decompensated HF. If stable HF, discuss.

    Adverse effects. Ankle edema, dizziness, facial flushing, headache, fatigue.

  4. Espironolactona 25mg/dia

    • If BP is not controlled with steps 1, 2, and 3 (or similar drugs) at the maximum or tolerated dose: start 25mg/day. Do not prescribe if pregnant.
    • If already on spironolactone and BP is not controlled after 4 weeks, discuss or refer.
    • Monitor potassium (K) and eGFR before starting and after 2 weeks.
    • If K ≥ 4.5 or eGFR ≤ 45: do not start, or stop, and discuss — consider carvedilol (step 5) instead.

    Efeitos adversos. Ginecomastia.

  5. Carvedilol 6.25–25mg 12/12h or propranolol 40–320mg 12/12h

    • If stable HF, ischemic heart disease, tachyarrhythmia, or a contraindication to spironolactone, and BP is not controlled: prescribe carvedilol 6.25mg every 12 hours. Increase every 4 weeks if BP is not controlled, up to 25mg (if > 85kg, 50mg) every 12 hours.
    • If there are no signs of HF and there is essential tremor, hyperthyroidism, or migraine: prescribe propranolol 40mg every 12 hours instead. Increase every 4 weeks if BP is not controlled, up to 320mg every 12 hours.
    • Do not prescribe either if decompensated HF or severe COPD/asthma. If HR < 60 before treatment, discuss.
    • If COPD or mild to moderate asthma, do not prescribe propranolol and discuss using carvedilol or alternatives.

    Adverse effects. Chest tightness, fatigue, bradycardia, headache, cold hands and feet, sexual impotence, orthostatic hypotension.

Reassess patients with uncontrolled BP every 4 weeks and patients with controlled BP every 6 months.

6. Simulations — second round (post-class)

7. Extra: extra simulations

Open the simulation

QR code that opens the hypertension simulation in SimulaPacientes
Hypertension — first visit after diagnosis.

Or open it directly: simulation link ↗

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